移植失败，卵巢早衰难好孕？怎么样才能提高试管成功率？
2020-03-12
Seven solutions can effectively improve the success rate of test tubes and save test tube costs!
01
Personalized precise test tube treatment (promotion plan)
A personal chemotherapy course is designed based on age and egg inventory AMH. A high AMH can get more eggs at a time with a strong stimulus, and a low AMH requires mild or micro stimulation. Avoid the use of a large amount of drugs, resulting in high costs and the waste of a large number of eggs. Try to use the few eggs left by the body after natural elimination. The quality is relatively low and the cost is relatively low.
02
IMSI
The low fertilization rate is related to the quality of sperm and eggs. At this time, you can only start with selecting sperm, and use an ultra-high magnification microscope to magnify the sperm to 6300 times (IMSI). From this, you can easily select sperm with normal appearance and no vacuoles, which can also improve the fertilization rate. But because the operation is more difficult than the general fertilization method (ICSI), only a few reproductive centers have been introduced.
03
Zygmy / zygotic strategy
Oviposition can be used if the number of eggs is small but less than 38 years old. Due to the good quality of young eggs, several sessions can be performed to collect more eggs, and then thawed and fertilized together, which can save the cost of each fertilization. If you are older than 38 years old, it is recommended to fertilize after each egg retrieval, collect enough blastocysts before planning transplantation. However, this strategy must be combined with good freezing and thawing techniques to avoid damage to the eggs and embryos during the process.
04
Blastocyst culture
During natural conception, the embryo will arrive in the uterine cavity at about 5 to 6 days to prepare for implantation. Therefore, if the embryo can be cultured to the blastocyst stage by in vitro tube technology, it is more in line with the physiological mechanism of the mother's uterine cavity. At the same time, blastocyst culture can eliminate unhealthy and delayed development of embryos, which is conducive to selecting high quality embryos for transplantation, and can achieve a higher pregnancy rate.
05
Third Generation Test Tube Baby (PGS)
When encountering unsuccessful transplantation or abortion or abortion, it is often disappointing and overwhelmed. Modern medicine has found that this is mainly due to embryo chromosomal abnormalities. Three-generation test tube (PGS) technology can detect embryo chromosomes and select Normal embryo retransplantation can increase the success rate.
The latest three-generation test tube technology uses the NGS platform, which can detect all 23 pairs of chromosomes. It is also more accurate, more informative, and takes less time than previous aCGH technologies.
06
Pre-transplant genetic diagnosis (PGD)
It is known that a spouse with a single-gene genetic disease, or who has a chromosomal translocation or fragment defect, must use the PGD method to detect the embryo. The detectable diseases include hemophilia, thalassemia, and rigid myelitis, which can avoid children. With the same genetic diseases.
07
Endometrial receptivity should be screened (ERA)
I have selected good embryos with normal chromosomes through PGS technology. Why is it possible that the transplantation fails? European studies have found that the endometrium can allow the embryo to implant only once a month. The general experience of previous doctors was that 120 hours after taking progesterone, transplants were possible, but the study found that up to 28.6% of people's endometrium is not at this time Open, transplantation fails at the wrong time and precious embryos are wasted. Endometrial receptive gene screening (ERA) can collect endometrial cells for more than 248 genetic tests, which can analyze the optimal implantation time of the endometrium, which can increase the success rate by about 10-20%.
Through three generations of test tubes (PGS) combined with endometrial receptive gene screening (ERA), a good blastocyst is implanted at a precise time, and the average pregnancy rate can reach 80%. However, for women with ovarian problems such as low ovarian inventory, low yield or poor propulsion response, premature ovarian failure, and other ovarian problems, pregnancy through their eggs is not only difficult, time and costly.
At this time, if you hope that the healthy eggs donated by young girls can reach the mother's wish as soon as possible, you will find that regular egg supply in domestic tertiary hospitals usually takes a long time, and underground egg supply is chaotic, unregulated and illegal, and the risk is high Therefore, it is suggested that families with a certain economic base can consider countries and regions that are legally compliant, such as Taiwan, Thailand, and the United States.
Taiwan began to provide eggs legally in 2007 with strict regulations. All data must be registered in detail and sent to the Ministry of Health and Welfare for record management to avoid the ethical problems of close relatives. They must also pass strict health inspections so that both oviparous girls and donor couples have Good protection. The cost is cheaper than the United States and Thailand, the language is convenient, and the transportation is convenient, which can be one of the preferred choices for donor eggs.
If you want to know more about test tubes in other countries, you can visit the 15th Shanghai International Medical Tourism Exhibition site, and you can meet face to face with reproductive centers in Thailand, the United States, Cambodia, Russia, Ukraine, Taiwan and other countries and regions
